PubMed · 13630326
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P JACOBSON. 1959. Pilonidal disease: management without excision.. https://pubmed.ncbi.nlm.nih.gov/13630326/
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Paraneoplastic disorders can affect any part of the central or peripheral nervous system. Although relatively uncommon, these disorders are a significant cause of severe neurologic disability among cancer patients. Many paraneoplastic disorders are believed to be caused by an autoimmune response directed against shared neural tumor antigens. This article summarizes the clinical features, possible autoimmune pathophysiology, and management issues for patients with paraneoplastic disorders.
Quality of care in Singapore has seen a paradigm shift from a traditional focus on structural approaches to a broader multidimensional concept which includes the monitoring of clinical indicators and medical errors. Strong political commitment and institutional capacities have been important factors for making the transition. What is still lacking, however, is a culture of rigorous programme evaluation, public involvement, and patient empowerment. Despite these imperfections, Singapore has made considerable strides and its experience may hold lessons for other small developing countries in the common quest for quality care and patient safety.