PubMed · 13661586
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R S ATKINSON. 1959. Continuous flow spirometry in anaesthesia.. https://doi.org/10.1111/j.1365-2044.1959.tb02428.x
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BACKGROUND: The value of the laryngeal tube S (LTS) for emergency airway management was evaluated in comparison to endotracheal intubation (ETI). METHODS: Physicians were asked to perform simulated airway management in an airway mannequin. The physicians were allocated into three groups according to their experience in intubation (1: <50, 2: >50, 3: >500 intubations). The success rate using LTS and ETI, the time needed for securing the airway, and the rating of both techniques by the participants were recorded. RESULTS: A correct position was achieved with the LTS in 99.39% of attempts (n=325), and with the endotracheal tube in 92.35% (n=302). Using the LTS it took an average time of 10.85 s to achieve the first successful ventilation, as compared to 17.75 s in ETI (p<0.0001). Participants from group 1 needed longer to achieve ETI in the 2nd (18.4 s vs. 16.4 s, p<0.0001) and 3rd attempts (16.9 s vs. 15.8 s, p<0.0001) compared to those from group 3. CONCLUSIONS: The LTS represents a fast and reliable method to secure the airway and to achieve ventilation in the mannequin model described. The success rate, the time until successful ventilation and the rating by the participants indicates that the LTS is an important alternative to ETI. The LTS offers special benefits for the less experienced users.
Carbon dioxide (CO(2))-pneumoperitoneum is known to favorably modify the systemic immune response during laparoscopic surgery. The presented studies were designed to determine whether treating animals with CO(2) abdominal insufflation before undergoing a lipopolysaccharide (LPS)-contaminated laparotomy would serve as "shock prophylaxis" and thus improve survival and attenuate cytokine production. Rats were randomized into five groups: CO(2)-pneumoperitoneum, helium-pneumoperitoneum, anesthesia control, laparotomy/LPS control, and LPS only control. Animals in the first four groups all received a laparotomy and a lethal dose of LPS. Immediately preceding their laparotomy, animals in the pneumoperitoneum groups received a 30-minute pretreatment of abdominal insufflation with either CO(2) or helium. The anesthesia control group received a 30-minute pretreatment of isoflurane. Animal mortality was then recorded during the ensuing 72 hours. Subsequently, a similar protocol was repeated for measurements of cytokines. CO(2)-pneumoperitoneum increased survival at 48 hours compared with LPS control (P <.05), and decreased interleukin-6 plasma levels at 2 hours (P <.05). Abdominal insufflation with CO(2) before the performance of a laparotomy contaminated with endotoxin increases survival and attenuates interleukin-6. The beneficial immune-modulating effects of CO(2)-pneumoperitoneum endure after abdominal insufflation. CO(2)-pneumoperitoneum pretreatment may improve outcomes among patients undergoing gastrointestinal surgery who are at high risk for abdominal fecal contamination.
BACKGROUND AND OBJECTIVE: The modified Airway Management Device (AMD) and the Proseal laryngeal mask airway (PLMA) are both supraglottic airway devices designed to maintain airway patency and allow ventilation during anaesthesia. In this prospective, randomized trial, we compared the two devices in patients undergoing major gynaecological procedures. METHODS: Eighty-two patients undergoing elective gynaecological surgery were randomized to two groups. Group A (n = 41) had the AMD and Group P (n = 41) the PLMA inserted after induction of anaesthesia. We compared the success of airway placement, time to achieve an airway, oropharyngeal leak pressure and complications associated during anaesthesia. RESULTS: There were no differences in patient characteristic profile for both groups. First time insertion success rates were significantly higher in Group P than in Group A (100% vs. 83%, P < 0.012). Time taken to achieve airway was also significantly shorter in Group P than in Group A (mean 21.9 +/- 7.8 s vs. 40.2 +/- 48.0 s, P < 0.001). The oropharyngeal leak pressure was significantly higher for Group P than Group A (mean 31.2 +/- 5.7 cmH(2)O vs. 24.2 +/- 8.3 cmH(2)O, P < 0.001). Ten patients in Group A had transient loss of airway during anaesthesia and needed manipulation of the airway device and four patients needed to have the airway switched to PLMA for the rest of the procedure. CONCLUSIONS: The modified AMD has a significant lower first time successful placement rate, required a longer insertion time and has a lower oropharyngeal leak pressure than the PLMA. It also demonstrated an increased loss of airway during anaesthesia. The modified AMD needs further evaluation on its efficacy and safety before its further use can be recommended.