Single chain antibody variable regions.

R E Bird; B W Walker

doi:10.1016/0167-7799(91)90044-i

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Single chain antibody variable regions.

R E Bird·B W Walker

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Abstract

The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to generate a continuous polypeptide chain, may be able to overcome some of these problems. Since these single chain antibody variable regions (scFvs), are transcribed from constructed 'genes', large-scale production in, for example, E. coli, should be straightforward.

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Animals Humans Immunoglobulin Heavy Chains Immunoglobulin Light Chains Immunoglobulin Variable Region Immunotoxins Protein Engineering Journal Article Review

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R E Bird, B W Walker. 1991. Single chain antibody variable regions.. https://doi.org/10.1016/0167-7799(91)90044-i

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