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Major histocompatibility complex binding peptides: a target for therapeutic development.

A Sette·P Wentworth·H M Grey
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Abstract

Peptides that bind with high affinity to major histocompatibility complex molecules could represent useful tools in treating class II-associated autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and multiple sclerosis. Although the concept has been validated in experiments with both purified receptor systems in vitro and cellular systems in vivo, many challenging problems need to be resolved before efficacious therapeutic agents are obtained.

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Autoimmune DiseasesForecastingHLA AntigensHumansImmune System DiseasesMajor Histocompatibility ComplexPeptidesJournal ArticleReview

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A Sette, P Wentworth, H M Grey. 1991. Major histocompatibility complex binding peptides: a target for therapeutic development.. https://doi.org/10.1016/s0958-1669(05)80125-9

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