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Rational immunotherapy with interleukin 2.

G Kaplan·Z A Cohn·K A Smith
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Abstract

Interleukin 2 (IL-2), a T lymphocyte product released upon antigen stimulation, has been used for cancer therapy in high doses for more than five years. More recently, its potential as a stimulant of cell-mediated immunity in infectious diseases, particularly those caused by intracellular microbes, has become appreciated. Drawing on the extensive information available as to the structure, cellular and molecular effects of IL-2, this review focuses on its use in patients with lepromatous leprosy and AIDS in low, physiologic doses. The data indicate that IL-2 is effective in stimulating cell-mediated immunity without systemic toxicity.

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HumansHypersensitivity, DelayedImmunotherapyInterleukin-2NeoplasmsReceptors, Interleukin-2Signal TransductionJournal ArticleReview

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BibTeXRIS

G Kaplan, Z A Cohn, K A Smith. 1992. Rational immunotherapy with interleukin 2.. https://doi.org/10.1038/nbt0292-157

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