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Affinity chromatography supports: a look at performance requirements.

S R Narayanan·L J Crane
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Abstract

Because of its high selectivity, affinity chromatography is a preferred tool in the downstream processing of high-value proteins and peptides of therapeutic interest. This review examines the affinity supports currently available, and investigates the performance characteristics and properties required of the support matrices for improved affinity-based supports for large-scale purification of biomolecules. Parameters for optimizing an affinity chromatographic process, and the advantages of affinity-based separation for scaled-up systems are highlighted.

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Chromatography, AffinityHumansImmunosorbentsLigandsPeptidesProteinsSepharoseSilicon DioxideJournal ArticleReview

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S R Narayanan, L J Crane. 1990. Affinity chromatography supports: a look at performance requirements.. https://doi.org/10.1016/0167-7799(90)90124-g

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