Poliovirus antigen chimeras.

C S Rose; D J Evans

doi:10.1016/0167-7799(91)90142-5

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Poliovirus antigen chimeras.

C S Rose·D J Evans

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Abstract

Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of hybrid viruses (chimeras) possessing novel antigenicity. The potential applications of these 'epitope-presentation systems' include their use as immunogens, as antigens for serodiagnosis, and as vaccines.

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Acquired Immunodeficiency Syndrome Amino Acid Sequence Antigens, Viral Base Sequence DNA, Viral HIV Antigens Molecular Sequence Data Poliovirus Recombinant Proteins Viral Vaccines Journal Article Research Support, Non-U.S. Gov't Review

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C S Rose, D J Evans. 1991. Poliovirus antigen chimeras.. https://doi.org/10.1016/0167-7799(91)90142-5

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