Protein-catalysed protein folding.

A L Horwich; W Neupert; F U Hartl

doi:10.1016/0167-7799(90)90153-o

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PubMed · 1369433

Protein-catalysed protein folding.

A L Horwich·W Neupert·F U Hartl

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Abstract

A number of proteins, termed chaperonins, have been identified as part of the mechanism of folding other proteins into their biologically active forms. The role of chaperonins appears to be twofold--to prevent illegitimate interactions with other proteins and to facilitate folding, possibly through an energy-dependent, catalytic function. Controlled overexpression of chaperonins may be of therapeutic value in manipulating human immune response and rescuing certain inherited human mutations.

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Chaperonin 60 Chaperonins Heat-Shock Proteins Protein Conformation Proteins Journal Article Review

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A L Horwich, W Neupert, F U Hartl. 1990. Protein-catalysed protein folding.. https://doi.org/10.1016/0167-7799(90)90153-o

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