X-chromosome inactivation and cell memory.

A D Riggs; G P Pfeifer

doi:10.1016/0168-9525(92)90219-t

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X-chromosome inactivation and cell memory.

A D Riggs·G P Pfeifer

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Abstract

Mammalian X-chromosome inactivation is an excellent example of the faithful maintenance of a determined chromosomal state. As such, it may provide insight into the mechanisms for cell memory, defined as the faithful maintenance of a determined state in clonally derived progeny cells. We review here the aspects of X-chromosome inactivation that are relevant to cell memory and discuss the various molecular mechanisms that have been proposed to explain its occurrence, with emphasis on DNA methylation and a recently proposed mechanism that depends on the timing of replication.

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Animals Cell Differentiation Clone Cells Dosage Compensation, Genetic Drosophila melanogaster Feedback Female Gene Expression Regulation Genomic Imprinting Heterochromatin Mammals Methylation Models, Genetic Journal Article Research Support, U.S. Gov't, P.H.S.Review

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A D Riggs, G P Pfeifer. 1992. X-chromosome inactivation and cell memory.. https://doi.org/10.1016/0168-9525(92)90219-t

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