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Cellular generators of the cortical auditory evoked potential initial component.

M Steinschneider·C E Tenke·C E Schroeder·D C Javitt·G V Simpson·J C Arezzo·H G Vaughan
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Abstract

Cellular generators of the initial cortical auditory evoked potential (AEP) component were determined by analyzing laminar profiles of click-evoked AEPs, current source density, and multiple unit activity (MUA) in primary auditory cortex of awake monkeys. The initial AEP component is a surface-negative wave, N8, that peaks at 8-9 msec and inverts in polarity below lamina 4. N8 is generated by a lamina 4 current sink and a deeper current source. Simultaneous MUA is present from lower lamina 3 to the subjacent white matter. Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells. Relationships to the human AEP are discussed.

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Acoustic StimulationAnimalsCerebral CortexElectroencephalographyEvoked Potentials, AuditoryMacaca fascicularisMaleJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M Steinschneider, C E Tenke, C E Schroeder, D C Javitt, G V Simpson, J C Arezzo, H G Vaughan. Cellular generators of the cortical auditory evoked potential initial component.. https://doi.org/10.1016/0168-5597(92)90026-8

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