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Current issues in maternal serum alpha-fetoprotein screening.

J L Bock
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Abstract

Measurement of maternal serum alpha-fetoprotein originated in the early 1970s as a means to screen for fetal neural tube defects, a relatively common and devastating class of malformations. Since that time, assay methods have improved, interpretation has been refined, follow-up testing for neural tube defects has advanced, and many other disease associations have been uncovered. It is a unique test, both in its clinical application and its laboratory implementation. The present review outlines current procedures for maternal serum alpha-fetoprotein screening and summarizes recent developments.

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Down SyndromeFemaleHumansNeural Tube DefectsPregnancyPrenatal Diagnosisalpha-FetoproteinsJournal ArticleReview

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BibTeXRIS

J L Bock. 1992. Current issues in maternal serum alpha-fetoprotein screening.. https://doi.org/10.1093/ajcp%2F97.4.541

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