A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids.

P Rossi; G Marziali; C Albanesi; A Charlesworth; R Geremia; V Sorrentino

doi:10.1016/0012-1606(92)90172-d

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A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids.

P Rossi·G Marziali·C Albanesi·A Charlesworth·R Geremia·V Sorrentino

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Abstract

We have cloned a novel c-kit mRNA of 3.2 kb expressed in postmeiotic male germ cells. This transcript initiates in the genomic region immediately upstream of the exon coding for the second box of the split c-kit tyrosine kinase domain. The open reading frame (ORF) contains 12 novel amino acids in frame with the C-terminal 190 amino acids of the c-kit protein. It lacks therefore the upstream region in the 5.5-kb c-kit mRNA encoding the extracellular and transmembrane domain, the ATP-binding site and the kinase insert domain present in the c-kit protein.

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Amino Acid Sequence Animals Base Sequence Chromosome Mapping Cloning, Molecular Introns Male Mice Molecular Sequence Data Proto-Oncogene Proteins Proto-Oncogene Proteins c-kit RNA, Messenger Spermatids Journal Article Research Support, Non-U.S. Gov't

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P Rossi, G Marziali, C Albanesi, A Charlesworth, R Geremia, V Sorrentino. 1992. A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids.. https://doi.org/10.1016/0012-1606(92)90172-d

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