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Nitric oxide: a pathogenetic factor in autoimmunity.

H Kolb·V Kolb-Bachofen
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Abstract

Nitric oxide (NO) has been identified recently as a multifunctional mediator, produced by, and acting on, most cells of the body. Besides its function as endothelium-derived relaxing factor, as a neurotransmitter and as an immune defence molecule, evidence is accumulating that NO participates in inflammatory- and autoimmune-mediated tissue destruction. Modulation of NO synthesis and action represents a new approach to the treatment of inflammatory and autoimmune conditions.

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Amino Acid OxidoreductasesAnimalsArginineAutoimmunityCalciumCell AdhesionCell DeathDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Enzyme InductionHumansInflammationIslets of LangerhansIsoenzymesMacrophage ActivationMiceNeutrophilsNitric OxideNitric Oxide SynthaseJournal ArticleResearch Support, Non-U.S. Gov'tReview

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H Kolb, V Kolb-Bachofen. 1992. Nitric oxide: a pathogenetic factor in autoimmunity.. https://doi.org/10.1016/0167-5699(92)90118-q

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