Ionic selectivity of volume-sensitive currents in human epithelial cells.

A Rasola; L J Galietta; D C Gruenert; G Romeo

doi:10.1016/0925-4439(92)90108-y

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Ionic selectivity of volume-sensitive currents in human epithelial cells.

A Rasola·L J Galietta·D C Gruenert·G Romeo

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Abstract

The ion selectivity of swelling-activated Cl- currents has been investigated in three different human epithelial cell lines, two derived from the airway epithelium (9HTEo- and CFNPE9o-) and one from a colon carcinoma (T84). The relative permeability of volume-sensitive currents with respect to Cl- is: I- (1.19) greater than NO3- (1.07) approximately Br-(1.05) greater than Cl-(1.0) greater than F-(0.5) approximately HCO3-(0.48) greater than isethionate(0.28) greater than aspartate (0.14) approximately gluconate(0.13) approximately SO4(2-)(0.12). This type of ion selectivity is similar to that described for depolarization-activated outwardly rectifying Cl- channels found in epithelial cells.

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Anions Cell Line Chloride Channels Chlorides Electric Conductivity Epithelial Cells Epithelium Humans Hypotonic Solutions Ion Channels Membrane Potentials Membrane Proteins Tumor Cells, Cultured Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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A Rasola, L J Galietta, D C Gruenert, G Romeo. 1992-08-25. Ionic selectivity of volume-sensitive currents in human epithelial cells.. https://doi.org/10.1016/0925-4439(92)90108-y

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