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PubMed · 13830164

[Vasodilator therapeutics].

P GUILLEMAN
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Vasodilator AgentsVASODILATOR AGENTS/therapyJournal Article

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P GUILLEMAN. 1959-09-01. [Vasodilator therapeutics].. https://pubmed.ncbi.nlm.nih.gov/13830164/

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PubMed1976

The synthesis of ethyl apovincaminate.

Starting from (+) vincamine (I), simple derivatives of vincaminic acid (II), apovincaminic acid (V) and apovincaminol (VII) were synthetized. Out of these the synthesis of ethyl apovincaminate (Cavinton), as a representative, is described in detail. The water elimination and esterification of II can be carried out in one step.

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