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PubMed · 1386687

The less common occupational dermatoses.

D J Hogan·C Tanglertsampan
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Abstract

Contact dermatitis and nonmelanoma skin cancer are the most common occupational skin disorders in North America, but there are many other occupational dermatoses that illustrate the wide range of pathological and adaptive responses of the skin to workplace exposure. Discussed are acne, chemically induced leukoderma, nail diseases, contact-related burns, high-pressure injection injuries, contact urticaria, heat reactions and photosensitivity, and infections.

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Burns, ChemicalDermatitis, ContactDermatitis, OccupationalHand DermatosesHumansNail DiseasesPhotosensitivity DisordersPigmentation DisordersUrticariaJournal ArticleReview

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D J Hogan, C Tanglertsampan. The less common occupational dermatoses.. https://pubmed.ncbi.nlm.nih.gov/1386687/

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Although the incidence of caustic ingestion is declining, the management of caustic esophageal strictures remains a challenge. Mitomycin C (MMC) inhibits fibroblast proliferation and is effective in reducing scar in animal experiments. We report the case of a child with a distal esophageal stricture from lye ingestion managed with MMC. Despite repeated dilatations, at 1 year post injury, the stricture was 20% of esophageal diameter. Mitomycin C (4 microg/mL) was applied topically and circumferentially by endoscopy and repeated 4 months later. At 20 months follow-up, the child eats normally, and esophagram showed decreased stenosis (stricture was 50% of esophageal diameter). No complications were observed. Although controlled trials are required to confirm its efficacy, MMC should be considered as an adjunct in the management of caustic esophageal strictures in children.

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