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A fail-safe mechanism for maintaining self-tolerance.

S Guerder·P Matzinger
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Abstract

Using cytotoxic T lymphocyte (CTL) responses to the class I histocompatibility antigen Qa1 and to the minor histocompatibility antigen H-Y, we show that the immune system maintains a peripheral screening process that is able to tolerize a wide variety of potentially autoimmune CTL. The critical factor is the presence or absence of specific T helper cells. If T help is available, CTL precursors that recognize antigen are activated. In the absence of help, they are tolerized. Thus, T helper cells are guardians of peripheral tolerance in CTL.

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AnimalsAutoimmunityCells, CulturedFemaleHaptensHistocompatibility Antigens Class IImmune ToleranceKineticsMaleMiceMice, Inbred BALB CMice, Inbred C57BLT-Lymphocytes, CytotoxicT-Lymphocytes, Helper-InducerJournal ArticleResearch Support, Non-U.S. Gov't

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S Guerder, P Matzinger. 1992-08-01. A fail-safe mechanism for maintaining self-tolerance.. https://doi.org/10.1084/jem.176.2.553

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