Capillary NMDA receptors regulate blood-brain barrier function and breakdown.

H Koenig; J J Trout; A D Goldstone; C Y Lu

doi:10.1016/0006-8993(92)91589-7

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Capillary NMDA receptors regulate blood-brain barrier function and breakdown.

H Koenig·J J Trout·A D Goldstone·C Y Lu

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Abstract

Polyamines and their regulatory synthetic enzyme ornithine decarboxylase (ODC) have been implicated in blood-brain barrier (BBB) breakdown following cryogenic injury. ODC activation and BBB breakdown are prevented by MK-801, indicating involvement of NMDA receptors. Studies in isolated rat cerebral capillaries supports the presence of NMDA receptors linked to ODC. NMDA (1-50 microM) stimulated capillary uptake of horseradish peroxidase, 2-deoxy-[14C]glucose, and 45 Ca in a receptor-, concentration-, polyamine- and Ca(2+)-dependent manner. We suggest that NMDA receptors may couple capillary transport of nutrients to glutamate-mediated neuronal excitation, and when overestimated disrupt normal BBB function.

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Animals Blood-Brain Barrier Brain Edema Capillaries Deoxyglucose Female Horseradish Peroxidase In Vitro Techniques Ornithine Decarboxylase Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Glutamate Receptors, N-Methyl-D-Aspartate Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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H Koenig, J J Trout, A D Goldstone, C Y Lu. 1992-08-21. Capillary NMDA receptors regulate blood-brain barrier function and breakdown.. https://doi.org/10.1016/0006-8993(92)91589-7

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