PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 1393663

[The HLA complex in 1991].

M Buc
View original source ↗Export metadata ↓

Abstract

In November 1990 the Nomenclature Committee of the WHO updated the designation of loci, alleles, and antigens of the HLA complex. Their complete list is presented in our review, along with current knowledge on the complexity of the HLA-D region. Finally, the paper deals with the tertiary structure of HLA antigens discovered in 1987, which has enabled us to understand the biological significance of the HLA complex. (Fig. 5, Tab. 5, Ref. 15.)

Explore related subjects

HLA AntigensHumansTerminology as TopicEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M Buc. 1992. [The HLA complex in 1991].. https://pubmed.ncbi.nlm.nih.gov/1393663/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Soluble HLA revisited.

The goal of this editorial is to revisit soluble human leukocyte antigens (sHLA) and to highlight the findings reported by Albitar et al. in this issue on the relation between sHLA levels in Non-Hodgkin's Lymphoma (NHL) and Hodgkin's Disease (HD). We will review key aspects of sHLA including soluble HLA-G, which has received a lot of attention in recent publications. We will then address the role of sHLA in lymphoproliferative diseases and in solid organ tumors. Lastly, we will comment on the results of Albitar et al. and their relevance to clinical application in NHL.

HLA Antigens↗
PubMed2006

Impact of KIR/HLA ligand combinations on immune responses in malignant melanoma.

Tumor growth and dissemination depend partly on the reactivity of natural killer (NK) cells and T cells expressing NK-associated receptors. Their effector functions are regulated by an array of activating and inhibitory cell surface receptors with MHC class I ligand specificity, such as the killer immunoglobulin-like receptors (KIRs). Given the extensive genomic diversity of KIRs and their HLA ligands, it is reasonable to speculate that HLA, KIR gene variations and specific KIR-ligand combinations will have an impact on disease susceptibility and/or progression. Here, we discuss how KIR genotypes and KIR/HLA immunogenetic profiles may be involved in tumorigenesis, especially in malignant melanoma (MM). A hypothetical model of the impact of KIR/ligand combinations on immune responses in MM is proposed.

HLA Antigens↗