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Acute severe combined demyelination.

R Amit·B Glick·Y Itzchak·Y Dgani·S Meyeir
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Abstract

We present a second case in which Guillain-Barré syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) appeared simultaneously, both in acute and fulminant form. The patient, a 10-year-old girl, presented with acute onset of coma and flaccid, are-flexic quadriparesis. The elevated CSF protein levels and delayed F waves fulfilled the criteria of GBS and an MRI study revealed extensive multifocal demyelination compatible with a diagnosis of ADEM. Prompt clinical response followed by complete recovery was achieved by treatment with corticosteroids. It is suggested that acute severe combined demyelination might constitute a separate entity in which the demyelinating process, involving simultaneously the central and the peripheral nervous systems, indicates immune response against a component of the myelin of one system carrying cross-antigenicity with the other.

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Acute DiseaseChildDemyelinating DiseasesEncephalomyelitisFemaleHumansPolyradiculoneuropathyCase ReportsJournal Article

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BibTeXRIS

R Amit, B Glick, Y Itzchak, Y Dgani, S Meyeir. 1992. Acute severe combined demyelination.. https://doi.org/10.1007/bf00296569

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