PubMed · 13945469
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
H FLEISCHHACKER. 1963. [Preleukemic states].. https://pubmed.ncbi.nlm.nih.gov/13945469/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
STUDY DESIGN: Collecting and analyzing all possible documents by internet, and consulting medical libraries in different countries. OBJECTIVE: To focus on the work of Ollivier d'Angers who, in the beginning of the 19th century, spent most of his professional life studying the spinal cord, marrow (SM), or medulla spinalis, and publishing the first comprehensive treatise on the subject in 1824. SETTING: ParaDoc database, Swiss Paraplegic-Centre, 6207 Nottwil, Switzerland, in collaboration with Paul Dollfus, ISCoS/Paradoc, Mulhouse, France. RESULTS: Some of d'Angers's clinical descriptions, observations and also pathologic findings, described in the successive editions of his treatise, were very much in advance of his time. CONCLUSIONS: To our knowledge, this was the first comprehensive treatise, in 1824, at least in France. It gave a clear picture on the matter of the SM and in that period of medical history.
OBJECTIVE: To describe the association between chondral defects, bone marrow lesions, knee and hip radiographic osteoarthritis (OA), and knee pain. METHODS: Knee pain was assessed by the Western Ontario and McMaster Universities Osteoarthritis Index. T1- and T2-weighted fat saturation magnetic resonance imaging was performed on the right knee to assess chondral defects and subchondral bone marrow lesions. Radiography was performed on the right knee and hip and scored for radiographic OA. Body mass index (BMI) and knee extension strength were measured. RESULTS: A total of 500 randomly selected men and women participated. The prevalence of knee pain was 48%. In multivariable analysis, prevalent knee pain was significantly associated with medial tibial chondral defects (odds ratio [OR] 2.32, 95% confidence interval [95% CI] 1.02-5.28 for grade 3 versus grade 2 or less; OR 4.93, 95% CI 1.07-22.7 for grade 4 versus grade 2 or less), bone marrow lesions (OR 1.44, 95% CI 1.04-2.00 per compartment), and hip joint space narrowing (OR 1.36, 95% CI 1.07-1.73 per unit), as well as greater BMI and lower knee extension strength. It was not significantly associated with radiographic knee OA. These variables were also associated with more severe knee pain. In addition, there was a dose response association between knee pain and number of sites having grade 3 or 4 chondral defects (OR 1.39, 95% CI 1.12-1.73 per site), with all subjects having knee pain if all compartments of the knee had these defects. CONCLUSION: Knee pain in older adults is independently associated with both full and non-full-thickness medial tibial chondral defects, bone marrow lesions, greater BMI, and lower knee extension strength, but is not associated with radiographic knee OA. The association between radiographic hip OA and knee pain indicates that referred pain from the hip needs to be considered in unexplained knee pain.
Bone marrow edema of the knee joint is a frequent clinical picture in MR diagnostics. It can be accompanied by symptoms and pain in the joint. Diseases that are associated with bone marrow edema can be classified into different groups. Group 1 includes vascular ischemic bone marrow edema with osteonecrosis (synonyms: SONK or Ahlbäck's disease), osteochondrosis dissecans, and bone marrow edema syndrome. Group 2 comprises traumatic or mechanical bone marrow edema. Group 3 encompasses reactive bone marrow edemas such as those occurring in gonarthrosis, postoperative bone marrow edemas, and reactive edemas in tumors or tumor-like diseases. Evidence for bone marrow edema is effectively provided by MRI, but purely morphological MR information is often unspecific so that anamnestic and clinical details are necessary in most cases for definitive disease classification.