PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 1401523

Analyzing reverse middle-ear transmission: noninvasive Gedankenexperiments.

C A Shera·G Zweig
View original source ↗Export metadata ↓

Abstract

The phenomenological framework outlined in the companion paper [C. A. Shera and G. Zweig, J. Acoust. Soc. Am. 92, 1356-1370 (1992)] characterizes both forward and reverse transmission through the middle ear. This paper illustrates its use in the analysis of noninvasive measurements of middle-ear and cochlear mechanics. A cochlear scattering framework is developed for the analysis of combination-tone and other experiments in which acoustic distortion products are used to drive the middle ear "in reverse." The framework is illustrated with a simple psychophysical Gedankenexperiment analogous to the neurophysiological experiments of P. F. Fahey and J. B. Allen [J. Acoust. Soc. Am. 77, 599-612 (1985)].

Explore related subjects

CochleaEar, MiddleHearingHumansOtoacoustic Emissions, SpontaneousPsychoacousticsScattering, RadiationJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

C A Shera, G Zweig. 1992. Analyzing reverse middle-ear transmission: noninvasive Gedankenexperiments.. https://doi.org/10.1121/1.403930

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

A model of peripherally developing hearing loss and tinnitus based on the role of hypoxia and ischemia.

The incidence of sensorineural hearing loss often caused by direct damage to the cochlear hair cells is by far more frequent and more serious than disorders affecting the external ear or the middle ear. Mechanisms that are discussed to be relevant for the genesis of tinnitus and acquired hearing impairment are hair cell loss, signal transduction disturbances in the region of the outer and inner hair cells and the spiral ganglion, impairment of cochlear blood flow, mechanical disturbance, and hypoxia and ischemia. The present model surveys the possible cellular and molecular biological causes of peripherally developing hearing loss and tinnitus. In particular, the paper discusses the roles of hypoxia and ischemia in the cochlea and in the etiology of the neurosensory types of tinnitus. Peripheral origins of hearing disturbances and tinnitus may be: (a) damage to the stereocilia and the tip links, (b) dysfunction of potassium channels or (c) modification of the glutamate release. Moreover, the hypoxia inducible factor-1 may have an important role to play as a key transcription factor in the cells' adaptation to hypoxia and ischemia. An impairment of the cochlear blood flow may be induced by the expression of target genes like nitrogen monoxide synthase and endothelin-1 resulting in tinnitus. The paper discusses consequences resulting from the present model for the medical treatment of peripherally developing tinnitus and hearing loss.

Cochlea↗