[Evaluation and selection of normal range calculation methods].

T Usui

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[Evaluation and selection of normal range calculation methods].

T Usui

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Abstract

There are many methods for normal range calculation, and they give different values even with the same normal data sample. I proposed three parameters, accuracy, precision and robustness, for evaluating the calculation methods. A complicated calculation method, the distribution selection method, seems to be theoretically correct, but it shows unstable precision and inadequate robustness when the normal data contain a small amount of abnormal data. A method called "Clinical reference range program (CRRP)" is a robust method, and is applicable to the data which contains abnormal data. I also proposed a condition which defines the sample size required for the calculation using the precision parameter.

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T Usui. 1992. [Evaluation and selection of normal range calculation methods].. https://pubmed.ncbi.nlm.nih.gov/1404954/

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