Immune complexes and complement catabolism in ankylosing spondylitis.

R Gabay; R H Zubler; U E Nydegger; P H Lambert

doi:10.1002/art.1780200402

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Immune complexes and complement catabolism in ankylosing spondylitis.

R Gabay·R H Zubler·U E Nydegger·P H Lambert

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Abstract

In serum samples from 37 patients with ankylosing spondylitis (AS), immune complexes were quantitated by the 125I-Clq binding test; in paired plasma samples the C3 breakdown product C3d was measured by an immunochemical method. Compared to results in 30 blood donors, the Clq binding activity was significantly (greater than 2 SD), although discretely, increased in 5 of 8 patients with seropositive AS, but not in other AS patients. All C3d levels were within the normal range. In a parallel investigation, increased Clq binding activity and C3d levels were found in 87% and 90%, respectively, of patients with seropositive rheumatoid arthritis.

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Antigen-Antibody Complex Arthritis, Rheumatoid Complement System Proteins Humans Immune Complex Diseases Protein Binding Spondylitis, Ankylosing Comparative Study Journal Article

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R Gabay, R H Zubler, U E Nydegger, P H Lambert. 1977. Immune complexes and complement catabolism in ankylosing spondylitis.. https://doi.org/10.1002/art.1780200402

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