PubMed · 14092030
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S SCHUJMAN. 1963-08-01. [THERAPEUTIC PSEUDOPREGNANCY].. https://pubmed.ncbi.nlm.nih.gov/14092030/
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N-Nitrozo-N-methylbiuret (NMB) in a concentration of 0.2% and exposition for 2,3,4 and 6 hours with the survival rate of the conidia of 4-25% induced slight morphological variation of the griseofulvin-producing organism and increased the variation rate with respect to the antibiotic production by 40-140%. Preliminary treatment of the conidia with NMB decreased the lethal effect of UV-rays approximately by 15-25 times. The protective range with respect to morphological variation was 10 times lower. With an increase in the toxicity of NMB its protective effect in irradiation with UV-light decreased.
The effect of some physical (increased temperature, UV light) and chemical (N-nitrosomethylbiuret, proflavin, acridine orange) factors on the virus titer in 2 strains of Penicillium chrysogenum was studied. Thermoinactivation of the virus and its induction under the effect of UV light and proflavin were shown. Slight induction was observed with N-nitrosomethylbiuret and acridin orange. It was supposed that induction of the virus in the mycelium of Penicillium chrysogenum was spontaneous.
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