PubMed · 14094664
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G VISCO, P G FASSIO. 1963-10-07. [PNEUMONIA].. https://pubmed.ncbi.nlm.nih.gov/14094664/
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A 4-year-old boy with Prader-Willi syndrome died suddenly while asleep on day 67 of growth hormone treatment. During treatment, snoring had worsened. Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive apnea, respiratory infection, and sudden death in this condition.
OF DEBATABLE INTEREST: Although the place of non-invasive ventilation (NIV) is indisputable in the management of acute respiratory failure during chronic obstructive pulmonary disease (COPD), where it significantly reduces the rate of intubation and complications and the number of days spent in intensive care, its interest is debated in the long term management of chronic obstructive respiratory failure (CORF). EFFICACY TO BE DEMONSTRATED: Although several short term studies confirm the efficacy of NIV on some physiological parameters and on the quality of sleep and quality of life in some patients, long term prospective studies are still too few and do not confirm these data on small series of patients and limited time. FOR CERTAIN CATEGORIES OF PATIENTS: It is legitimous to consider that sub-groups of patients respond to NIV, notably in cases of instable CORF non-controlled by medical treatments or by well-conducted kinesitherapy and oxygentherapy.
Varicella or chicken-pox are one of the most frequent diseases in childhood. Severe or even lethal complications are rare (in about 0.03 per thousand ). Our paper presents two cases of varicella infections leading to sudden deaths (3- and 7-year-old children). In one of these cases, the paediatrician in charge was accused of an impaired medical treatment. Both of the children showed multiple typical efflorescences in different stages. Furthermore were observed affections of the respiratory tracts and serious involvements of the hearts, the lungs, and the livers. In one case an immunological identification could be made of an acute varicella infection. Based on autoptical, histological, bacteriological, virological, and neuropathological findings is given an analysis of such uncommon and severe courses of chicken-pox in children being identified as haemorrhagic form and massive abscess-forming varicella pneumonia.