[Changes in cellular radiosensitivity by modifying the cytoplasmic membranes].

M S Iarova; A G Pribush; L I Fedorova; I G Abidor; A N Petrov; A V Kulikov

PubMed · 1410294

[Changes in cellular radiosensitivity by modifying the cytoplasmic membranes].

M S Iarova·A G Pribush·L I Fedorova·I G Abidor·A N Petrov·A V Kulikov

Abstract

The radiosensitivity of mouse myeloma and E. coli cells in the presence of Mg2+ and UO2(2+) ions has been investigated. It has been shown that Mg2+ ions (10(-4) M) do not influence the viability of E. coli and mouse myeloma cells. The presence of Mg2+ ions during irradiation reduces the survival rate of E. coli cells, but the addition of Mg2+ ions after irradiation does not influence the radiosensitivity of E. coli cells. Comparison of the results on the influence of Mg2+ ions upon cells and bilayer lipid membranes (BLM) permits us to suppose that Mg2+ ions increase the positive charge of the membranes thus promoting the increase in the number of short-lived radiolysis products which impair membranes and increase cell radiosensitivity. UO2(2+) ions (10(-4) M) increase the radioresistance of E. coli cells which can be associated with the increase in the lateral membrane viscosity, as it was shown in the studies on BLM.

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Animals Cell Membrane Cell Survival Dose-Response Relationship, Radiation Escherichia coli Lipid Bilayers Magnesium Membrane Lipids Mice Multiple Myeloma Radiation Tolerance Tumor Cells, Cultured Uranium Uranium Compounds Comparative Study Journal Article

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M S Iarova, A G Pribush, L I Fedorova, I G Abidor, A N Petrov, A V Kulikov. [Changes in cellular radiosensitivity by modifying the cytoplasmic membranes].. https://pubmed.ncbi.nlm.nih.gov/1410294/

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