Is leishmaniasis ever cured?

R A de Rossell; R J de Duran; O Rossell; A M Rodríguez

doi:10.1016/0035-9203(92)90297-p

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Is leishmaniasis ever cured?

R A de Rossell·R J de Duran·O Rossell·A M Rodríguez

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Abstract

The persistence of parasites in mice cured of Leishmania mexicana infection was investigated by using immunosuppressive drugs and checking for the reappearance of lesions. BALB/c (susceptible) and C57BL/6 (partially resistant) mice infected with 10(4) amastigotes were treated with either thermotherapy or meglumine antimonate and subsequently immunosuppressed with either cyclophosphamide or hydrocortisone. Immunosuppression by either method caused lesions to reappear in both strains of mice regardless of the treatment used to produce clinical cure. In both strains of mice the proportion of animals developing lesions after immunosuppression was greater in the mice cured by the drug. The relevance of these findings to human therapy is discussed.

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Animals Hyperthermia, Induced Immunosuppression Therapy Leishmania mexicana Leishmaniasis, Cutaneous Mice Mice, Inbred BALB C Mice, Inbred C57BL Recurrence Journal Article Research Support, Non-U.S. Gov't

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R A de Rossell, R J de Duran, O Rossell, A M Rodríguez. Is leishmaniasis ever cured?. https://doi.org/10.1016/0035-9203(92)90297-p

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