PubMed · 14163464
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G MAYER, M KLEIN, J M MEUNIER. [BIOLOGY OF THE PROGESTATIVE FUNCTION].. https://pubmed.ncbi.nlm.nih.gov/14163464/
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The prehistory of cyclical development of corpus luteum goes back to early follicular phase. Reduced secretion or defective rhythm of gonadotropin releasing hormone (GnRH) can later cause unperfect ovulation or corpus luteum insufficiency. The authors carried out a low-dose pulsatory GnRH-treatment on eight patients with luteal insufficiency, who were earlier treated unsuccessfully with other ovulation-inductive methods (clomiphene, hCG, bromocryptin). As a result of GnRH administration hypertherm period expanded, plasma progesteron level increased and three pregnancies occurred. In their opinion exogenic administration of GnRH results in an improvement of luteal function.
Radio-immunological assay was used to determine progesterone concentrations in serum during the luteal phase in 34 patients with treated and untreated corpus luteum insufficiency. Twenty patients with normal menstruation cycles were used as controls. Progesterone levels were found to be in agreement with the histological pattern of the endometrium. Progesterone values obtained from serial radio-immunological assay thus are high-accuracy criteria for diagnosis and therapeutic monitoring of corpus luteum insufficiency.
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