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PubMed · 1418713

T helper cells.

R Noelle·E C Snow
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Abstract

B-cell proliferation and differentiation is controlled by T helper cells. Recent studies have determined that the expression of a novel, 39 kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.

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AnimalsB-LymphocytesHumansLymphocyte ActivationSignal TransductionT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerJournal ArticleReview

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BibTeXRIS

R Noelle, E C Snow. 1992. T helper cells.. https://doi.org/10.1016/0952-7915(92)90085-s

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