Structure, function and evolutionary relationship of proteins containing a disintegrin domain.

C P Blobel; J M White

doi:10.1016/0955-0674(92)90098-w

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Structure, function and evolutionary relationship of proteins containing a disintegrin domain.

C P Blobel·J M White

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Abstract

Disintegrins are soluble integrin ligands from snake venoms that disrupt cell-matrix interactions. Recently, the nuclear magnetic resonance structures of two disintegrins were determined, providing provocative molecular insight into how a disintegrin may engage an integrin. In addition, it has recently been realized that disintegrins are derived from larger multifunctional proteins, and that there is a family of membrane-anchored, disintegrin domain-containing proteins that may promote important cell-cell interactions.

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Amino Acid Sequence Animals Biological Evolution Cell Adhesion Disintegrins Humans Membrane Proteins Molecular Sequence Data Oligopeptides Peptides Platelet Aggregation Inhibitors Proteins Sequence Homology, Amino Acid Venoms Journal Article Review

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C P Blobel, J M White. 1992. Structure, function and evolutionary relationship of proteins containing a disintegrin domain.. https://doi.org/10.1016/0955-0674(92)90098-w

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