PubMed · 14211518
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L VADOT. 1964. [MATERIAL AND TECHNIC FOR SIMPLIFIED EXTRA-CORPOREAL CIRCULATION].. https://pubmed.ncbi.nlm.nih.gov/14211518/
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Concurrent administration of radiation and chemotherapy has emerged as a dominant form of cancer treatment. Nevertheless, our understanding of the specific mechanisms of interaction between radiation and chemotherapy is still evolving. Biological evidence gained in experimental cell lines and tumors suggests that cisplatin lesions cause repair inhibition of radiation-induced DNA damage affecting both homologous recombination and nonhomologous end joining. In the case of 5-fluorouracil (5-FU), the crucial event in the radiosensitisation process appears to be inappropriate progression through S-phase in the presence of bound drug affecting both DNA repair and cell cycle. In similar fashion, data with gemcitabine suggest that radiosensitization arises through progression into S-phase causing depletion of 2'-deoxyadenosine 5'-triphosphate pools, which leads to misincorporation and misrepair of incorrect bases in irradiated cells. As the new molecular-targeted agents become increasingly available to complement established radiation and chemoradiation treatment regimens, new concepts of drug-radiation interaction are evolving that require innovative thinking regarding the manner in which radiation and drugs cooperate and how clinical trials are best performed.
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We study light propagation in biological tissue containing an absorbing obstacle. In particular, we solve the infinite-domain problem in which an absorbing plate of negligible thickness prevents a portion of the light from the source from reaching the detector plane. Inasmuch as scattering in the medium is sharply peaked in the forward direction, we replace the governing radiative transport equation with the Fokker-Planck equation. The problem is solved first by application of the Kirchhoff approximation to determine the secondary source distribution over the surface of the plate. That result is propagated to the detector plane by use of Green's function. The Green's function is given as an expansion of plane-wave modes that are calculated numerically. The radiance is shown to obey Babinet's principle. Results from numerical computations that demonstrate this theory are shown.