An extended view of nuclear lamin structure, function, and dynamics.

M R Paddy; D A Agard; J W Sedat

doi:10.1016/1043-4682(92)90027-s

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An extended view of nuclear lamin structure, function, and dynamics.

M R Paddy·D A Agard·J W Sedat

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Abstract

Molecularly-based studies of nuclear lamins have progressed at a rapid rate in the last decade. However, we still have no answer to the most important question: what are the functions of lamins? In this review we describe recent experiments which challenge traditional views of lamin function and structure. These surprising results indicate that much lamin functionality remains to be discovered, and that more global approaches to lamin structure and function are especially appropriate at this time.

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Animals CDC2 Protein Kinase Drosophila melanogaster Intermediate Filament Proteins Interphase Lamins Mitosis Nuclear Envelope Nuclear Matrix Nuclear Proteins Phosphorylation Protein Processing, Post-Translational Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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M R Paddy, D A Agard, J W Sedat. 1992. An extended view of nuclear lamin structure, function, and dynamics.. https://doi.org/10.1016/1043-4682(92)90027-s

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