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Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats.

M Diana·M Pistis·A Muntoni·Z L Rossetti·G Gessa
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Abstract

The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.

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AnimalsDopamineEthanolMaleNucleus AccumbensRatsRats, Sprague-DawleySubstance Withdrawal SyndromeJournal Article

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M Diana, M Pistis, A Muntoni, Z L Rossetti, G Gessa. 1992-10-20. Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats.. https://doi.org/10.1016/0014-2999(92)90734-l

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