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PubMed · 1428101

Dose-response relationships in carcinogenesis.

D Krewski·M J Goddard·J M Zielinski
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Abstract

Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view. Emphasis is placed on the application of biologically based models to describe observed dose-response relationships for exposure to single and multiple agents known to increase cancer risk. The implications of these observations for inferences about possible mechanisms of carcinogenesis are explored.

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AnimalsCarcinogensDose-Response Relationship, DrugDose-Response Relationship, RadiationHumansNeoplasmsNeoplasms, Radiation-InducedRadiation DosageJournal ArticleReview

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D Krewski, M J Goddard, J M Zielinski. 1992. Dose-response relationships in carcinogenesis.. https://pubmed.ncbi.nlm.nih.gov/1428101/

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