PubMed · 14288629
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
S M PHILLIPS, S E KORNGUTH, H G THOMPSON. 1965. SERUM HAPTOGLOBIN CHANGES IN MULTIPLE SCLEROSIS.. https://doi.org/10.1212/wnl.15.5.415
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Monoclonal gammopathies of undetermined significance constitute a body of asymptomatic diseases characterized by a selective increase of a single serum immunoglobulin due to an only dysregulated clone of B lymphocytes. They occur in up to 10% of persons over 80 years of age. The diagnosis is suggested in presence of both M component in serum <30 g/L and bone marrow plasma cells <10% by the exclusion of multiple myeloma or lymphoproliferative disorders. In most MGUS, however, populations of normal and myelomatous plasma cells coexist in a stable ratio. The overall relative risk for progression is 7 times the expected rate, depending from the disease and the type of M component.
Diffuse pulmonary hemorrhage denotes a diffuse bleeding into the alveoli as a result of severe damage of the alveolocapillary membrane. Autoimmune diseases, toxic injury and hemodynamic changes are the most frequent causes. A 45 year old male patient presented with diffuse alveolar hemorrhage. An Immunoglobulin A (IgA) paraprotein secreting myeloma was found to be the underlying cause. Immunohistochemistry revealed dense pericapillary and perivascular deposits of IgA, indicating a paraprotein mediated damage of the alveolocapillary membrane. The predominantly vascular pattern of damage was regarded as the most likely cause of the pulmonary hypertension in this patient. The diffuse pulmonary bleeding stopped after initiation of treatment consisting of vincristine, adriamycine and dexamethasone.
Bisalbuminemia is a rare inherent or acquired abnormality characterized by the occurrence of 2 distinct albumin bands or a single widened albumin band, after electrophoretic screening of blood proteins. Despite the fact that the presence of 2 albumin bands in electrophoresis, representing normal and variant protein, is observed with a frequency of 0.00030.0010 in the average population, its role in various pathological states has not yet been clearly defined. Until now, the only disorders which have been directly linked with the presence of congenital bisalbuminemia are familial dysalbuminemic hyperthyroxinemia (Arg218AEHis and Arg218AE Pro mutations) and hypertriiodothyroninemia (Leu66AEPro mutation), while acquired types of bisalbuminemia have been reported after an overdose of beta-lactam antibiotics and as a consequence of severe pancreatitis. We present a case of bisalbuminemia in an adult man who was referred to our laboratory with a prolonged history of recurrent abdominal pain and review the recent literature in order to better familiarize clinicians as well as laboratory personnel with this entity. The biochemical parameters assessed did not show any alteration which could correlate the protein disorder with any distinct pathology.