PubMed · 14288845
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S GLOEREN, M MALL-HAEFELI. [THE ABORTION PROBLEM].. https://pubmed.ncbi.nlm.nih.gov/14288845/
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BACKGROUND: There are only a few reports regarding the fertility and outcome of pregnancy in Wilson's disease (WD) and none from India. The authors in this study discuss various aspects of fertility in 16 women with WD. METHODS: Retrospective analysis of data from a large cohort of WD, being followed at a tertiary care center. RESULTS: Sixteen patients had conceived on 59 occasions with 30 successful pregnancies, 24 spontaneous abortions, 2 medical terminations of pregnancy and 3 still births. Diagnosis of WD was established after conception in 10 presymptomatic patients while six patients were already on treatment. Among these 16 patients, 9 had history of spontaneous abortions and 12 had successful pregnancies. None of the clinical features of WD changed during pregnancy, with or without treatment. All the 30 babies were full-term and delivered healthy. CONCLUSION: Recurrent abortions are common especially in women with untreated Wilson's disease. However, successful pregnancies and uneventful full-term delivery may occur in mothers of WD on treatment and in undiagnosed, undetected presymptomatic patients. Pregnancy does not seem to have adverse effect on the clinical course of Wilson's disease. Teratogenecity was not seen in the present series with low-dose penicillamine and zinc sulphate.
We reviewed 86 consecutive cases with fetal femur length (FL) below the 10th centile of our reference ranges at midtrimester ultrasonography. Three groups were identified based on perinatal outcome: normal infants (n= 28), newborns with structural and/or chromosomal anomalies (n= 40), small-for-gestational age (SGA) newborns (n= 18). Fetuses with skeletal dysplasias (n= 13) had significantly shorter FL. Aneuploidies were only found in fetuses with malformations other than skeletal dysplasias. The diagnosis of SGA, based on ultrasound abdominal circumference measurement <10th centile, was made 9 weeks (range 5-14) after the finding of a short FL. Half of these cases also developed pre-eclampsia.
PURPOSE: An optional half-day clinical experience in abortion care was offered to third-year medical students rotating through the core obstetrics and gynecology (Ob/Gyn) clerkship at the University of New Mexico to improve education about women's reproductive health. This study using survey methods was conducted to rate the acceptability of the clinical experience and to document any changes in students' attitudes toward women's access to abortion. METHOD: All 145 students who rotated through the Ob/Gyn clerkship between March 2000 and March 2002 were provided an 11-item, confidential questionnaire to complete. Students who did not participate in the abortion care experience were asked questions about their reasons for declining participation; students who did participate were asked questions about the value of the experience. RESULTS: Of the 145 students who rotated through the clerkship during the study period, 126 (87%) completed the questionnaire. Of these students, 86 (68%) participated in the clinical experience and 40 (32%) did not. The majority of students who participated in the clinical experience rated it very highly. Of the 86 students who participated in the clinical experience, 33 (38%) reported a change in their attitudes about abortion; 31 (94%) of these became more supportive of women's access to abortion services. CONCLUSION: Clinical experiences in abortion care are acceptable to and valued by a diverse group of medical students and should be offered at medical schools throughout the United States.