Major histocompatibility complex-linked transport proteins and antigen processing.

J J Monaco

doi:10.1007/bf02918617

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Major histocompatibility complex-linked transport proteins and antigen processing.

J J Monaco

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Abstract

The major histocompatibility complexes of mice, rats and humans each contain a pair of related genes, Tap-1 and Tap-2, that encode members of a large superfamily of proteins having similar structure and function. The TAP-1 (previously called HAM1 in the mouse) and TAP-2 (HAM2) proteins each contain 6-8 predicted membrane-spanning alpha helices, and a cytoplasmic domain containing a putative ATP-binding site. Recent evidence suggests that a functional TAP-1/TAP-2 heterodimer is required for efficient presentation of antigens to CD8+ cytotoxic T cells. This heterodimer resides in the membrane of the endoplasmic reticulum (ER), and probably functions to transport peptides (produced in the cytoplasm) into the ER lumen for binding to MHC class I molecules.

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ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP-Binding Cassette Transporters Amino Acid Sequence Animals Biological Transport, Active Carrier Proteins Genes, MHC Class I Genes, MHC Class II Histocompatibility Antigens Class II Humans Immunologic Deficiency Syndromes Major Histocompatibility Complex Molecular Sequence Data Sequence Alignment Comparative Study Journal Article Review

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J J Monaco. 1992. Major histocompatibility complex-linked transport proteins and antigen processing.. https://doi.org/10.1007/bf02918617

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