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PubMed · 1433966

[Function, molecular structure and gene expression of interleukin-1].

T Kasahara·K Kuno·K Matsushima
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Abstract

Recent cloning of human and murine IL-1 receptor (IL-1R) has revealed that there are at least two type of IL-1R: type I IL-1R is detected on T cells and fibroblasts and consists of 552 AAs with a cytoplasmic domain of 213 AAs, while type II is detected on B cells and monocytic cell lines and consists of 398 AAs with a short stretch intracytoplasmic domain of 29 AAs. Extracytoplasmic portion of IL-1R has some homology with vaccinia virus B15 Ag or fibroblast protein ST-2, while cytoplasmic portion has considerable similarity with Drosophila toll gene. By transfecting murine type I IL-1R cDNA into a human Jurkat cell line, structural and functional potion required for the IL-1 signal transduction is determined. At least broad portion of cytoplasmic domain including 364-474 AAs from N-terminus are found to be essential, while PKC acceptor site (Ser-431 and Ser-509), and PKA acceptor site (Ser-528) are not essential for the IL-8 gene expression.

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Amino Acid SequenceHumansInterleukin-1Molecular Sequence DataMolecular StructureReceptors, Interleukin-1Signal TransductionEnglish AbstractJournal ArticleReview

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T Kasahara, K Kuno, K Matsushima. 1992. [Function, molecular structure and gene expression of interleukin-1].. https://pubmed.ncbi.nlm.nih.gov/1433966/

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