[Function, molecular structure and gene expression of IL-4].

T Noma

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PubMed · 1433969

[Function, molecular structure and gene expression of IL-4].

T Noma

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Abstract

Interleukin-4 (IL-4) is a T-lymphocyte-derived 20-kDa glycoprotein that has a broad spectrum of biological activity including growth and differentiation of T cells, B cells, mast cells, hematopoietic cells and non-hematopoietic cells. The biological effects of IL-4 are induced by binding to specific membrane receptors (IL-4R) on target cells. Molecular cloning of IL-4R revealed a novel cytokine receptor family, but not clues as to the signalling mechanism. The biochemical mechanism of IL-4 signal, induced by its specific binding, remains to be clarified. Recent studies on the physiological function of IL-4 are presented here.

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Amino Acid Sequence Animals Humans Interleukin-4 Mice Mice, Transgenic Molecular Sequence Data Signal Transduction English Abstract Journal Article Review

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T Noma. 1992. [Function, molecular structure and gene expression of IL-4].. https://pubmed.ncbi.nlm.nih.gov/1433969/

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