[Function, molecular structure and gene expression of IL-8].

S Okamoto; H Nomura; K Matsushima

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PubMed · 1433973

[Function, molecular structure and gene expression of IL-8].

S Okamoto·H Nomura·K Matsushima

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Abstract

Interleukin-8 (IL-8) is a potent chemotactic factor for neutrophils and T lymphocytes. Various reagents such as lectins, mitogens, IL-1, TNF, induce IL-8 production in a wide range of cells and tissues. The IL-8 gene is known to be activated by AP-1, NF-kB like factor and C/EBP like factor, but the relative importance of these transcriptional factors varies from cell to cell. Two types of human IL-8 receptor cDNA have recently been cloned. Both are G-protein coupled receptors and the amino acid sequences are highly homologous. Other members of the IL-8 family, such as GRO/MGSA and MIP2, bind to IL-8 receptors, and the receptors of other chemoattractants such as fMLP and C5a, show high homology to the IL-8 receptors.

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Amino Acid Sequence Animals Cloning, Molecular Gene Expression Regulation Humans Interleukin-8 Molecular Sequence Data Receptors, Immunologic Receptors, Interleukin-8A Signal Transduction English Abstract Journal Article Review

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S Okamoto, H Nomura, K Matsushima. 1992. [Function, molecular structure and gene expression of IL-8].. https://pubmed.ncbi.nlm.nih.gov/1433973/

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