CHEMODECTOMA.

BACKGROUND: Carotid body tumors (CBT) are rare, infrequently malignant vascular neoplasms that are near the carotid bifurcation. Surgical excision is the treatment of choice, but individual surgeons or an institution cannot accumulate sufficient expertise to evaluate their outcomes with confidence. Our purpose was to report outcomes of surgical procedures for CBT from a nationwide dataset. STUDY DESIGN: Data were retrieved from the Nationwide Inpatient Sample from nonfederal hospital discharge abstracts. Data were queried for ICD-9-CM code 39.8, operations on the carotid body and vascular bodies, and code 38.2, carotid endarterectomy. Outcomes analyzed were length of stay, charges, and in-hospital mortality. RESULTS: An estmated 4,601 operations were identified, 3,746 for CBT surgical procedures only, and in 855 a carotid endarterectomy was also performed. Overall morbidity was 3.3%. Mortality with CBT alone was 2.0% but was 8.8% if carotid endarterectomy was also performed. CBT surgical procedures are most commonly performed in western states where higher elevations are found. Women constituted 59% of the population; mortality for women was higher than for men (12.4% versus 7.9%). Mortality in urban teaching hospitals was 2.1% and in nonteaching hospitals 4.9%. CONCLUSIONS: CBT surgical procedures are rare but are performed across a broad age spectrum. Mortality rate is low for patients having CBT alone but rises when CE is added. Women are more commonly affected and fare less well. Addition of CE to CBT surgical procedures and the resulting poor outcomes have not been previously described. Consideration should be given to referral of CBT patients to hospitals where mortality rates are low.

Carotid Body Tumor↗

PubMed2004

Paragangliomas of the head and neck.

Paragangliomas are neuroendocrine tumors derived from the extra-adrenal paraganglia of the autonomic nervous system. Within the head and neck, they are generally defined and named according to their site of origin, and may be found frequently neighboring vascular structures. Physiologic activity is rare in these neoplasms and they may exhibit patterns of inheritance which predispose their occurrence in families, often with multicentricity. These tumors generally exhibit a slow rate of growth, most often presenting asymptomatically as a space occupying mass lesion noted clinically or radiographically. The most common paraganglioma of the head and neck is the carotid body tumor followed by the jugulo-tympanic and vagal varieties. Other rare sites where this tumor may occur include; the larynx, sinonasal chambers and orbit. Diagnosis is generally made through a combination of clinical findings and radiographic studies. Magnetic resonance represents the most important imaging modality for the evaluation and characterization of suspected head and neck paraganglioma. Definitive management for these lesions should be carefully considered in relation to both tumor and patient-oriented factors, especially in regard to the potential morbidity of treatment. Surgery and radiation therapy represent the main treatment modalities for paraganglioma. The selection of treatment depends on the size, location, and biologic activity of the tumor as well as the overall fitness of the patient. Although radiotherapy may be effective in arresting growth of these tumors, rarely is the neoplasm eliminated without surgical resection. Surgery may be associated with significant morbidity, primarily as a consequence of incurring major cranial nerve injury. Patient selection (relative to age and medical condition) should be carefully considered prior to recommending aggressive surgery for paragangliomas of head and neck, especially in those patients at risk for disabling surgical morbidity.

Carotid Body Tumor↗