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Morphine antagonists.

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F H SHAW, A SHULMAN. 1955-02-26. Morphine antagonists.. https://doi.org/10.1038/175388b0

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Diastereoselective synthesis of 3,4-dimethoxy-7-morphinanone: a potential route to morphine.

[reaction: see text] Diastereoselective synthesis of racemic 3,4-dimethoxy-7-morphinanone from racemic 2-(2,3-dimethoxyphenyl)cyclohexen-1-ol has been achieved. The relative structure has been determined by transformation of the product into the known 3, 4-dimethoxy-6-morphinanone. Resolution of the starting cyclohexenol has also been accomplished for use in a future enantiocontrolled synthesis of morphine.

Morphine↗

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Morphine↗