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PubMed · 1438082

ATP-dependent protease in human placenta.

A Ishii·S Watabe·H Hamada
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Abstract

We have found that human placental mitochondria contain ATP-dependent protease in a soluble form. The molecular weight of the protease have been up to 108,000, which is the same as ATP-dependent protease in bovine adrenal cortex. Since this protease has been distributed among steroid hormone-producing tissues such as testis and adrenal cortex and ATP-dependent protease can degrade cytochrome P-450scc, a key enzyme in steroid hormone biosynthesis, we suggest that the protease may have an important role in the regulation of steroid hormone metabolism.

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ATP-Dependent ProteasesAdenosine TriphosphateCaseinsFemaleHeat-Shock ProteinsHumansImmunoblottingMitochondriaPlacentaPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdSerine EndopeptidasesJournal Article

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A Ishii, S Watabe, H Hamada. ATP-dependent protease in human placenta.. https://doi.org/10.1016/0143-4004(92)90058-2

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