PubMed · 14438320
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P ROETTGEN. 1960-06-10. [Acupuncture].. https://doi.org/10.1055/s-0028-1112539
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This paper examines the ways in which the acupuncture phenomenon is translated into scientific language through the mobilization of functional magnetic resonance imaging. In doing so, it explores how differences between science and traditional medicine are bridged and negotiated through an open-ended tuning process among heterogeneous elements. By showing the constructive interaction between traditional medicine and science, I aim to refute a conception of East Asian medicines as culturally bounded and to provide an interpretation of transculturalism that emphasizes its diverse and hybrid formations. Particularly, in order to explain the scientific translation of acupuncture, I refer to Andrew Pickering's "mangle of practice" as an alternative to Thomas Kuhn's paradigm. Adopting a performative perspective rather than a representational one with regard to science, I read the scientific interpretation of acupuncture as an interactive stabilization between the acupuncture phenomenon, neurological theory, and the material procedure of the MRI machine.
Acupuncture needle rotation has been previously shown to cause specific mechanical stimulation of subcutaneous connective tissue. This study uses acupuncture to investigate the role of mechanotransduction-based mechanisms in mechanically-induced cytoskeletal remodeling. The effect of acupuncture needle rotation was quantified by morphometric analysis of mouse tissue explants imaged with confocal microscopy. Needle rotation induced extensive fibroblast spreading and lamellipodia formation within 30 min, measurable as an increased in cell body cross sectional area. The effect of rotation peaked with two needle revolutions and decreased with further increases in rotation. Significant effects of rotation were present throughout the tissue, indicating the presence of a response extending laterally over several centimeters. The effect of rotation with two needle revolutions was prevented by pharmacological inhibitors of actomyosin contractility (blebbistatin), Rho kinase (Y-27632 and H-1152), and Rac signaling. The active cytoskeletal response of fibroblasts demonstrated in this study constitutes an important step in understanding cellular mechanotransduction responses to externally applied mechanical stimuli in whole tissue, and supports a previously proposed model for the mechanism of acupuncture involving connective tissue mechanotransduction.