PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 14441544

[Hemoglobin disorders in the Upper Volta. Statistical study].

H SANSARRICQ·G MARILL·A PORTIER·R CABANNES
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

Burkina FasoHemoglobinopathiesHemoglobinsHumansHEMOGLOBINJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H SANSARRICQ, G MARILL, A PORTIER, R CABANNES. 1959. [Hemoglobin disorders in the Upper Volta. Statistical study].. https://pubmed.ncbi.nlm.nih.gov/14441544/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine.

The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has moreover been shown to selectively inhibit the Plasmodium falciparum glutathione reductase. In 2004, an uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso (CQ monotherapy had a > 50% clinical failure rate in this area in 2003). Three serious adverse events (SAE) occurred of which one was probably attributable to the study medication. In the per protocol safety analysis, there were no dose specific effects. The overall clinical and parasitological failure rates by day 14 were 10% [95% CI (7.5%, 14.0%)] and 24% [95% CI (19.4%, 28.3%)], respectively. MB appears to have efficacy against malaria, but the combination of CQ-MB is clearly not effective in the treatment of malaria in Africa.

Burkina Faso↗