PubMed · 14442443
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F SCHAPOSNIK, R R RODRIGUEZ, S MELI, F ITURRIZA. 1959-04-10. [Experimental thallotoxicosis].. https://pubmed.ncbi.nlm.nih.gov/14442443/
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In 1951 Denny-Brown and Porter described the successful treatment of Wilson's disease using the chelating agent British antilewisite. The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder. The authors review the importance of these reports and provide edited digital versions of the films Denny-Brown made of the five patients described in the initial reports.
There now exists a number of approaches that can be used to predict likely responses to therapy and disease progression in idiopathic pulmonary fibrosis. These tools should be used in management decisions. It must be remembered that destroyed, fixed fibrotic lung will not improve and that the computed tomography pattern and extent of the "fibrotic" pattern should be used to determine if the best response to treatment that can be expected is a prevention of deterioration rather than improvement.
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