PubMed · 14465994
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F B LIVINGSTONE. 1961. Balancing the human hemoglobin polymorphisms.. https://pubmed.ncbi.nlm.nih.gov/14465994/
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In this study, we used the distribution rank, which has been developed by us over the past several years, to quantify 134 mutations in the human hemoglobin alpha-chain in order to gain an insight into the general pattern in mutations. The results suggest that the pattern presented by distribution rank can approximately estimate the positions that are sensitive to mutations in human hemoglobin alpha-chain.
A simple method is proposed for visualizing the depth distribution of a local blood region in skin tissue by using diffuse reflectance images at two isosbestic wavelengths of hemoglobin, 420 and 585 nm. Monte Carlo simulation of light transport specifies a relation between optical densities and the depth of the region under given concentrations of melanin in the epidermis and blood in the dermis. Phantom and in vivo experiments were performed to show the usefulness of the method.
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