PubMed · 14466607
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V LOPEZ MERINO, M FERRIS SANTES. 1962-03-31. [A new bronchodilator agent: TH-152].. https://pubmed.ncbi.nlm.nih.gov/14466607/
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The influence of relative humidity (RH) on the cohesion properties of three drugs: salbutamol sulphate (SS), triamcinolone acetonide (TAA), and disodium cromoglycate (DSCG) was investigated using the atomic force microscope (AFM) colloidal probe technique. Micronized drug particles were mounted in heat-sensitive epoxy resin for immobilization. Multiple AFM force-distance curves were conducted between each drug probe and the immobilized drug particulates at 15, 45, and 75% RH using Force-Volume imaging. Clear variations in the cohesion profile with respect to RH were observed for all three micronized drugs. The calculated force and energy of cohesion to separate either micronized SS or DSCG increased as humidity was raised from 15 to 75% RH, suggesting capillary forces become a dominating factor at elevated RH. In comparison, the separation force and energy for micronized TAA particles decreased with increased RH. This behavior may be attributed to long-range attractive electrostatic interactions, which were observed in the approach cycle of the AFM force-distance curves. These observations correlated well with previous aerosolization studies of the three micronized drugs.
Pharmaceutical manufacturing of semisolid matrices a past meeting two requirements: sufficient fluidity and sufficient viscosity. Ideally, the paste should have strong viscosity associated with a high dissolution rate. We studied the correlation between the viscosity and dissolution rate of polyethylene glycol (PEG) semisolid matrices (SSM) enclosing theophylline as a tracer. Nine formulations containing PEG of different molecular masses were studied. This work revealed the singularity of PEG binary mixtures. For pharmaceutical manufacturing, the conclusion of this work is that PEG binary mixtures enable circumventing the generally verified constraint: strong viscosity involves low dissolution ability.
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