Struvite urolithiasis in a B6C3F1 mouse.

Z W Wojcinski; R C Renlund; N J Barsoum; G S Smith

doi:10.1258/002367792780745742

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Struvite urolithiasis in a B6C3F1 mouse.

Z W Wojcinski·R C Renlund·N J Barsoum·G S Smith

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Abstract

In a 2 year carcinogenicity bioassay using B6C3F1 mice, one male mouse developed clinical signs near termination of the study, comprising skin sores around the prepuce, penile prolapse and urine scalding. The predominant finding at necropsy was a markedly distended urinary bladder filled with numerous crystallized particles. Microscopically, there was subacute cystitis with marked hyperplasia of the transitional epithelium. X-ray diffraction analysis of the crystals showed a diffraction pattern characteristic of struvite (ammonium magnesium phosphate). The implications of the spontaneous occurrence of bladder stones in rodents on long-term toxicology studies are discussed.

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Animals Crystallization Cystitis Female Magnesium Magnesium Compounds Male Mice Mice, Inbred C3H Mice, Inbred C57BL Phosphates Rodent Diseases Struvite Urinary Calculi X-Ray Diffraction Case Reports Journal Article

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Z W Wojcinski, R C Renlund, N J Barsoum, G S Smith. 1992. Struvite urolithiasis in a B6C3F1 mouse.. https://doi.org/10.1258/002367792780745742

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